Yes I have used it in my bike it hasn't caused any vibration or handling problems.
I have had a puncture in the front wheel last November and it fix it and it has stayed fixed with no air loss. Before I installed it I did alot of research into tyre sealants and this is the most advanced available.
Previously I had used Ultraseal and this was not very good but I think that great advances have been made by Puncturesafe and there product really does work.
It can even be used at speeds up to 150mph (not that I ever do that)!!!!!!!!!!!!